Analyse de données de cytométrie en flux et de masse

Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patients. Beretta L, Barturen G, Vigone B, Bellocchi C, Hunzelmann N, De Langhe E, Cervera R, Gerosa M, Kovács L, Ortega Castro R, Almeida I, Cornec D, Chizzolini C, Pers JO, Makowska Z, Lesche R, Kerick M, Alarcón-Riquelme ME, Martin J; PRECISESADS SSc substudy group; PRECISESADS Flow Cytometry study group. Ann Rheum Dis. 2020 Sep; 79(9):1218-1226.

Standardization procedure for flow cytometry data harmonization in prospective multicenter studies. Le Lann L, Jouve PE, Alarcón-Riquelme M, Jamin C, Pers JO; PRECISESADS Flow Cytometry Study Group; PRECISESADS Clinical Consortium. Sci Rep. 2020 Jul 14; 10(1):11567.

Delayed persistence of elevated monocytic MDSC associates with deleterious outcomes in septic shock: a retrospective cohort study. Waeckel L, Venet F, Gossez M, Monard C, Rimmelé T, Monneret G. Crit Care. 2020 Apr 7; 24(1):132.

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases. Barturen G, Babaei S, Català-Moll F, Martínez-Bueno M, ... , Jouve PE, et al. medRxiv2020.02.21.20021618.

Analyse de données omiques

Dysregulation of microRNA expression in the skin during cutaneous adverse drug reactions. Pedruzzi E, Chasset F, Richard I, Boccara D, Apparailly F, Nourikyan J, Lumy M, De Bernard S, Bonduelle O, Buffat L, Combadiere B, Soria A. Allergy. 2020 Jun 23. doi: 10.1111/all.14464.

Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling. Huyghe A, Furlan G, Ozmadenci D, Galonska C, Charlton J, Gaume X, Combémorel N, Riemenschneider C, Allègre N, Zhang J, Wajda P, Rama N, Vieugué P, Durand I, Brevet M, Gadot N, Imhof T, Merrill BJ, Koch M, Mehlen P, Chazaud C, Meissner A, Lavial F. Nat Cell Biol. 2020 Apr; 22(4):389-400.

KLF4 inhibition promotes the expansion of keratinocyte precursors from adult human skin and of embryonic-stem-cell-derived keratinocytes. Fortunel NO, Chadli L, Coutier J, Lemaître G, Auvré F, Domingues S, Bouissou-Cadio E, Vaigot P, Cavallero S, Deleuze JF, Roméo PH, Martin MT. Nat Biomed Eng. 2019 Dec; 3(12):985-997.

Gene profile of zebrafish fin regeneration offers clues to kinetics, organization and biomechanics of basement membrane. Nauroy P, Guiraud A, Chlasta J, Malbouyres M, Gillet B, Hughes S, Lambert E, Ruggiero F. Matrix Biol. 2019 Jan; 75-76:82-101.

Antigen-Induced but Not Innate Memory CD8 T Cells Express NKG2D and Are Recruited to the Lung Parenchyma upon Viral Infection. Grau M, Valsesia S, Mafille J, Djebali S, Tomkowiak M, Mathieu AL, Laubreton D, de Bernard S, Jouve PE, Ventre E, Buffat L, Walzer T, Leverrier Y, Marvel J. J Immunol. 2018 Apr 9. pii: ji1701698.

Human Dermal Fibroblast Subpopulations Display Distinct Gene Signatures Related to Cell Behaviors and Matrisome. Nauroy P, Barruche V, Marchand L, Nindorera-Badara S, Bordes S, Closs B, Ruggiero F. J Invest Dermatol. 2017 Aug; 137(8):1787-89.

MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis. Bauer Y, White ES, de Bernard S, Cornelisse P, Leconte I, Morganti A, Roux S, Nayler O. ERJ Open Res. 2017 Mar; 3(1).

Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge. Blanc P, Moro-Sibilot L, Barthly L, Jagot F, This S, de Bernard S, Buffat L, Dussurgey S, Colisson R, Hobeika E, Fest T, Taillardet M, Thaunat O, Sicard A, Mondière P, Genestier L, Nutt SL, Defrance T. Nat Commun. 2016 Dec; 7:13600.

Immune signatures of protective spleen memory CD8 T cells. Brinza L, Djebali S, Tomkowiak M, Mafille J, Loiseau C, Jouve PE, de Bernard S, Buffat L, Lina B, Ottmann M, Rosa-Calatrava M, Schicklin S, Bonnefoy N, Lauvau G, Grau M, Wencker M, Arpin C, Walzer T, Leverrier Y, Marvel J. Sci Rep. 2016 Nov; 6:37651.

CD1d-restricted peripheral T cell lymphoma in mice and humans. Bachy E, Urb M, Chandra S, Robinot R, Bricard G, de Bernard S, Traverse-Glehen A, Gazzo S, Blond O, Khurana A, Baseggio L, Heavican T, Ffrench M, Crispatzu G, Mondière P, Schrader A, Taillardet M, Thaunat O, Martin N, Dalle S, Le Garff-Tavernier M, Salles G, Lachuer J, Hermine O, Asnafi V, Roussel M, Lamy T, Herling M, Iqbal J, Buffat L, Marche PN, Gaulard P, Kronenberg M, Defrance T, Genestier L. J Exp Med. 2016 May; 213(5):841-57.

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection. van Helden MJ, Goossens S, Daussy C, Mathieu AL, Faure F, Marçais A, Vandamme N, Farla N, Mayol K, Viel S, Degouve S, Debien E, Seuntjens E, Conidi A, Chaix J, Mangeot P, de Bernard S, Buffat L, Haigh JJ, Huylebroeck D, Lambrecht BN, Berx G, Walzer T. J Exp Med. 2015 Oct; 212(12):2015-25.

A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis. Bauer Y, Tedrow J, de Bernard S, Gibson KF, Juan Guardella B, Hess P, Klenk A, Lindell KO, Renault B, Rey M, Weber E, Nayler O, Kaminski N. Am J Respir Cell Mol Biol. 2015 Feb; 52(2):217-31.

Dramatic response of a BRAF pV600E-mutated, primary CNS histiocytic sarcoma, to vemurafenib. Idbaih A, Mokhtari K, Emile JF, Galanaud D, Belaid H, de Bernard S, Benameur N, Barlog VC, Psimaras D, Donadieu J, Carpentier C, Martin-Duverneuil N, Haroche J, Feuvret L, Zahr N, Delattre JY, Hoang-Xuan K. Neurology. 2014 Oct; 83(16):1478-80.

T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. J Exp Med. 2014 Mar 10; 211(3):563-77.

Retinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo. Samarut E, Gaudin C, Hughes S, Gillet B, de Bernard S, Jouve PE, Buffat L, Allot A, Lecompte O, Berekelya L, Rochette-Egly C, Laudet V. Mol Endocrinol. 2014 Feb; 28(2):260-72.

A new Vitreoscilla filiformis extract grown on spa water-enriched medium activates endogenous cutaneous antioxidant and antimicrobial defenses through a potential Toll-like receptor 2/protein kinase C, zeta transduction pathway. Mahe YF, Perez MJ, Tacheau C, Fanchon C, Martin R, Rousset F, Seite S. Investig Dermatol. 2013 Aug; 6:191-6.

Differentially expressed androgen-regulated genes in androgen-sensitive tissues reveal potential biomarkers of early prostate cancer. Altintas DM, Allioli N, Decaussin M, de Bernard S, Ruffion A, Samarut J, Vlaeminck-Guillem V. PLoS One. 2013 Jun; 8(6):e66278.

SNP array analysis reveals novel genomic abnormalities including copy neutral loss of heterozygosity in anaplastic oligodendrogliomas. Idbaih A, Ducray F, Dehais C, Courdy C, Carpentier C, de Bernard S, Uro-Coste E, Mokhtari K, Jouvet A, Honnorat J, Chinot O, Ramirez C, Beauchesne P, Benouaich-Amiel A, Godard J, Eimer S, Parker F, Lechapt-Zalcman E, Colin P, Loussouarn D, Faillot T, Dam-Hieu P, Elouadhani-Hamdi S, Bauchet L, Langlois O, Le Guerinel C, Fontaine D, Vauleon E, Menei P, Fotso MJ, Desenclos C, Verelle P, Ghiringhelli F, Noel G, Labrousse F, Carpentier A, Dhermain F, Delattre JY, Figarella-Branger D; POLA Network. PLoS One. 2012; 7(10):e45950.

Biological pathways and networks in pharma discovery strategies: From information source to innovative insight. Hradecky P, de Bernard S, Stanislawski P, Buffat L. European Biopharma Review. 2005 (Spring) 70-4.

Analyse de données médicales

AVAPS-AE versus ST mode: A randomized controlled trial in patients with obesity hypoventilation syndrome. Patout M, Gagnadoux F, Rabec C, Trzepizur W, Georges M, Perrin C, Tamisier R, Pépin JL, Llontop C, Attali V, Goutorbe F, Pontier-Marchandise S, Cervantes P, Bironneau V, Portmann A, Delrieu J, Cuvelier A, Muir JF. Respirology. 2020 Feb 13. doi: 10.1111/resp.13784.

Hyperoxia During Exercise: Impact on Adenosine Plasma Levels and Hemodynamic Data. Boussuges A, Rives S, Marlinge M, Chaumet G, Vallée N, Guieu R, Gavarry O. Front Physiol. 2020 Feb 11; 11:97.

Mental Workload Alters Heart Rate Variability, Lowering Non-linear Dynamics. Delliaux S, Delaforge A, Deharo J-C and Chaumet G. Front Physiol. 2019; 10:565.

A Cross-Sectional Study Assessing the Contributions of Body Fat Mass and Fat-Free Mass to Body Mass Index Scores in Male Youth Rugby Players. Gavarry O, Lentin G, Pezery P, Delextrat A, Chaumet G, Boussuges A, Piscione J. Sports Med Open. 2018 May 2; 4(1):17.

Observational study of potential risk factors of immersion pulmonary edema in healthy divers: exercise intensity is the main contributor. Boussuges A, Ayme K, Chaumet G, Albier E, Borgnetta M, Gavarry O. Sports Med Open. 2017 Oct; 3(1):35.